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    Durham, NC Commercial Real Estate for Lease

    155 results
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    NC, Durham - 3511 Shannon Road
    Contact for pricing

    NC, Durham - 3511 Shannon Road

    Discover many ways to work your way in NC, Durham - 3511 Shannon Road

    3511 Shannon Rd, Durham, NC 27707
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    Versatile Office/Medical Space Available
    $3,000 / Mo
    2,400 SF

    Versatile Office/Medical Space Available

    3925 N Duke St, Durham, NC 27704

    2400 sq ft office/medical suite in prime Durham location.

    • Prime Durham location, minutes from downtown and Duke Regional Hospital.
    • Versatile 2400 sq ft space suitable for office, medical, or service‑based businesses.
    • Five private offices plus open central workspace.
    • Previously configured for dental and salon use.
    • Large reception area ideal for client‑facing businesses.
    Updated: Feb 18
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    Durham Office Condo For Lease
    $1,500 / Mo
    478 SF

    Durham Office Condo For Lease

    3201 Yorktown Ave, Durham, NC 27713

    Recently remodeled office condo with easy access and great location.

    • Recently remodeled with new paint, flooring, ceilings, light fixtures, updated bathroom and kitchenette, and new HVAC system
    • Easy access from parking lot
    • Convenient location: Minutes to Hwy 40 and 885
    • Proximity to Amenities: 2 Miles to Lowes Shopping Plaza, 4 Miles to RTP, 5 Miles to Southpoint Mall and Downtown Durham
    • Includes a brand new refrigerator
    Updated: Feb 10
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    Office Condo in Durham's Office Park
    $3,500 / Mo
    2,000 SF

    Office Condo in Durham's Office Park

    Office condominium with private entrance in a convenient location.

    6 Consultant Pl, Durham, NC 27707
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    Office Suite with Private Offices
    $36,000
    1,760 SF

    Office Suite with Private Offices

    Office suite featuring multiple private office spaces for rent.

    5315 Highgate Dr, Durham, NC 27713
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    Durham Office Space For Lease
    $45,045
    2,145 SF

    Durham Office Space For Lease

    Flexible office unit with ample parking and recent upgrades.

    1906 A, Durham, NC 27713
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    NC, Durham - Spaces Mangum Street
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    NC, Durham - Spaces Mangum Street

    We offer workspace options fully tailored to your needs in NC, Durham - Spaces Mangum Street

    555 Mangum St, Durham, NC 27701
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    Office Space Near Universities
    $1,995 / Mo
    1,000 SF

    Office Space Near Universities

    Office space in Durham, close to amenities and universities.

    1804 Martin Luther King Junior Pkwy, Durham, NC 27707
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    RTP Meridian
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    RTP Meridian

    Discover many ways to work your way in RTP Meridian

    2530 Floors, Durham, NC 27713
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    RTP Imperial
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    RTP Imperial

    Discover many ways to work your way in RTP Imperial

    4819 Emperor Blvd, Durham, NC 27703
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    Retail Space Near RTP
    $3,232 / Mo
    1,168 SF

    Retail Space Near RTP

    Retail space in a vibrant neighborhood center near RTP.

    5125 Nc-55, Durham, NC 27713
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    Downtown Durham Retail Space Available
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    12,473 SF

    Downtown Durham Retail Space Available

    Prime retail spaces in Durham's vibrant downtown area.

    400 West Main St, Durham, NC 27701
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    Downtown Durham Office Space Available
    Contact for pricing

    Downtown Durham Office Space Available

    Office spaces for lease in the heart of downtown Durham.

    433 W Main St, Durham, NC 27701
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    Prime Medical Office Space Available
    $18 SF/Yr
    2,312 SF

    Prime Medical Office Space Available

    Versatile medical/office space in Durham's thriving North Duke corridor.

    2609 N Duke St Unit Bldg 300, Durham, NC 27704
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    Professional Office Condos For Lease
    $2,400 / Mo
    5,120 SF

    Professional Office Condos For Lease

    Office condos for lease near Duke University Medical Center.

    2741 Campus Walk Ave, Durham, NC 27705
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    Plug and Play Lab Space
    $30 SF/Yr

    Plug and Play Lab Space

    Move-in ready lab and office space in Durham, NC.

    4025 Stirrup Creek Dr, Durham, NC 27703
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    Downtown Durham Office Space
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    27,941 SF

    Downtown Durham Office Space

    Centrally located office space in historic Durham tower.

    411 West Chapel Hill St, Durham, NC 27701
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    Retail Space in North Durham
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    22,425 SF

    Retail Space in North Durham

    Retail and restaurant spaces available in a busy shopping center.

    3500 North Roxboro St, Durham, NC 27704
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    Downtown Durham Office Space Available
    $32 SF/Yr
    25,678 SF

    Downtown Durham Office Space Available

    Suites available in historic Art Deco building, downtown Durham.

    331 W Main St, Durham, NC 27707
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    Durham Medical/Office Building for Lease
    $23 SF/Yr

    Durham Medical/Office Building for Lease

    Freestanding 4,769 SF building suitable for medical or office use.

    110 E Carver St, Durham, NC 27704
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    Roxboro Road Professional Office Space
    $20 SF/Yr
    2,408 SF

    Roxboro Road Professional Office Space

    Office space ideal for professional services and medical offices.

    4210 N Roxboro St, Durham, NC 27704
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    Class A Office Space
    $23 SF/Yr

    Class A Office Space

    Class A office space for lease in North Durham.

    4321 Medical Park Dr, Durham, NC 27704
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    Retail Space in Power Center
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    3,760 SF

    Retail Space in Power Center

    Retail space available in a power center location.

    4001 Durham Chapel Hill Blvd, Durham, NC 27707
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    Downtown Durham Office Space
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    Downtown Durham Office Space

    Full floor office space in downtown Durham's iconic tower.

    212 West Main St, Durham, NC 27701
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    Durham, NC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Durham, NC with 313 listings featured on our commercial real estate exchange. The current inventory includes 107,790,570,360 square feet of properties with an estimated lease value of $1,485 /Mo.

    Estimated lease rates for Commercial real estate in Durham, NC begin at $0.80 SF/Yr, with an average of $25 SF/Yr and extend to $60 SF/Yr.
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