Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    AI Search
    The Largest CRE Database in the US with Over 1 Million Listings

    442 Littlefield Ave So San Francisco, CA

    View on Map
    Loading data...
    Loading data...
    Loading data...
    For Lease
    Contact for pricing

    24,351 SF lab and office space available for lease.

    Type:LIFE_SCIENCE
    Property size:
    24,351 SF
    Lot size:
    1.38 Acres
    Added:
    Sep 8, 2025
    Days on Market:
    207
    Last Refresh:
    Mar 29 at 10:49 pm

    Property Features for 442 Littlefield Ave So

    General Information

    Standard status
    Active
    Size
    24,351 SF
    Lot size
    1.38 Acres
    Property subtype
    LIFE_SCIENCE

    Spaces For Lease

    at 442 Littlefield Ave So Contact us

    We can help!

    Listing Contact
    Chris Jacobs

    Listing agent Chris Jacobs

    Listing office CBRE | San Francisco

    Listing date Sep 8, 2025

    Source Moodyscre

    Displayed information is deemed reliable but is not guaranteed and should be independently verified.

    All listing content including descriptions, pricing, images are the copyrighted material of CBRE | San Francisco

    Overview

    South San Francisco Lab Space

    This 24,351 square foot property in South San Francisco, CA, offers a combination of flex space, industrial, and office functionalities. The space is configured as a biology lab, chemistry lab, and fermentation lab, and includes an autoclave and GMP clean room. It is equipped with eight fume hoods and tissue culture facilities. The office area features a break area, an open office area, three conference/board rooms, and 31 private offices. This property is suitable for a range of uses.
    Location Intelligence

    Current Use by Public Records

    Flex space

    Similar Places Nearby

    • Cochinita — 428 11th St, San Francisco, CA 94103
    • Models On The Run Catering — 140 S Van Ness Ave UNIT 403, San Francisco, CA 94103
    • Mission Bay Foods — 2 Henry Adams St # M95, San Francisco, CA 94103
    • DESTINO — 1817 Market St, San Francisco, CA 94103
    • Hardwood Bar & Smokery — 680 8th St, San Francisco, CA 94103

    Map

    City
    San Francisco
    County
    San Mateo
    State
    California
    Longitude
    -122.412
    Latitude
    37.776

    Nearby Similar for Lease

    • Contact for pricing

      Turnkey Medical Office in Union Square

      Semi-private 547 SF medical office space for lease.
      490 Post Street 1554, San Francisco, CA 94102
      View Details
    • Contact for pricing

      Retail Storefront in San Francisco

      Newly constructed retail space with modern design and great street presence.
      1525 Franklin Street, San Francisco, CA 94109
      View Details
    • Contact for pricing

      Prime Retail Space on Mission

      High-visibility retail space with consistent foot traffic in San Francisco.
      5654 Mission Street, San Francisco, CA 94112
      View Details
    • $30/mo

      Mission District Retail Space Available

      Prime retail space in vibrant Mission District location for lease.
      3327 24th Street, San Francisco, CA 94110
      View Details
    • Contact for pricing

      San Francisco Commercial Space Available

      Two-story commercial building in Lower Nob Hill for rent.
      729 Bush Street, San Francisco, CA 94108
      View Details
    • $39/mo

      Versatile Space on Taraval Street

      Adaptable space for medical, dental, retail use in San Francisco.
      2143-2145 Taraval St, San Francisco, CA 94112
      View Details
    • Contact for pricing

      Adaptable Retail/Office/Light Industry Space

      Adaptable space suitable for retail, office, or light industry.
      868 Post St, San Francisco, CA 94109
      View Details
    • $60/mo

      Mission District Tech Office Space

      High-end office space in vibrant Mission District, San Francisco.
      3043 Mission, San Francisco, CA 94110
      View Details
    • Sponsored
      Contact for pricing

      CA, San Francisco - 71 Stevenson St

      71 Stevenson St, San Francisco, CA 94105
      View Details
    • Contact for pricing

      CA, San Francisco - 101 Montgomery

      101 Montgomery St, Unit 900, San Francisco, CA 94111
      View Details
    • Contact for pricing

      CA, San Francisco - 720 Market St

      720 Market St, San Francisco, CA 94210
      View Details
    • Contact for pricing

      Inner Richmond Apartment Near Clement

      Charming 2-bedroom apartment near Clement Street's vibrant amenities.
      390 Arguello Blvd, Unit 5, San Francisco, CA 94118
      View Details

    FAQs

    What type of property is this?
    Flex space - 24,351 SF lab and office space available for lease.
    Where is this flex space located?
    The property is located at 442 Littlefield Ave So San Francisco, CA.
    What are key features of this property?
    This property features: GMP clean room available; Biology Lab on site; Chemistry Lab included
    (415) 772-0123 Call to check price and availability
    We can help!
    Contact for Pricing
    Please call us for current price
    and status of this listing
    Chris Jacobs
    Learn More
    Request Owner's contact information
    Message sent successfully
    Error
    If you are the owner or broker of this property and would like to edit or remove this listing please send a message to web site administrator.
    Message sent successfully
    Error
    Email to Your Friends
    Link copied to clipboard
    Separate multiple addresses with a comma
    Message sent successfully
    Error

    Realmo Value Estimations

    Realmo estimates a property’s market value using a proprietary methodology that incorporates public data and user-submitted information. This cumulative value is generated by integrating a variety of conventional and innovative methods. 

    Disclaimer

    These figures are not official appraisals and should not be used as a substitute for a valuation performed by a licensed appraiser.
    Actual market value may differ due to factors not captured in the data. Estimates are offered for informational purposes only, and users should conduct independent research before making financial or investment decisions.
    By using this feature, you acknowledge that Realmo is not responsible for actions taken based on these estimates.

    AI approach

    Realmo AI Method estimates property value using machine learning models trained on millions of comparable listings, transactions, and market signals. It analyzes property features, location intelligence data, and current market dynamics to predict the most probable market value in real time.

    Realmo CapRate Calculation

    Realmo calculates the Capitalization Rate (Cap Rate) to help estimate a property's potential return on investment. The Cap Rate is a fundamental metric in commercial real estate that measures the relationship between a property's net operating income and its market value.

    How We Calculate Cap Rate

    Cap Rate Formula:
    Cap Rate (%) = (Net Operating Income / Property Value) × 100

    Net Operating Income (NOI) Formula:
    NOI = Area × Lease Rate × (1 - Vacancy Rate) × (1 - Operating Expense Ratio)

    Components

    Net Operating Income (NOI) represents the annual income a property generates after operating expenses:

    • Area: Building square footage from property records
    • Lease Rate: Annual $/sqft based on market data for the property type and geographic location
    • Vacancy Rate: Percentage of unoccupied space based on market data for the property type and location
    • Operating Expense Ratio: Operating costs as a percentage of income, varies by property type

    Property Value is derived from:

    • Recent sale price (if available)
    • Statistical models using comparable sales
    • AI-powered valuation estimates

    Example Calculation

    For a 100,000 sqft Office Building:

    • Lease Rate: $25.00/sqft/year (market data for Office in this area)
    • Vacancy Rate: 8% (market data for Office in this area)
    • Operating Expense Ratio: 35% (typical for Office properties)
    • Property Value: $15,000,000

    Step 1: Calculate NOI

    NOI = 100,000 × $25.00 × (1 - 0.08) × (1 - 0.35)
    NOI = 100,000 × $25.00 × 0.92 × 0.65
    NOI = $1,495,000/year

    Step 2: Calculate Cap Rate

    Cap Rate = ($1,495,000 / $15,000,000) × 100
    Cap Rate = 9.97%

    Property Type Considerations

    Net Operating Income calculations vary by property type due to different operating expense ratios:

    • Office: Higher expenses (30-40%) for HVAC, utilities, maintenance
    • Retail: Moderate expenses (25-35%) for common area maintenance
    • Industrial/Warehouse: Lower expenses (15-25%) for minimal tenant services
    • Multifamily: Moderate expenses (35-45%) including property management
    • Self-Storage: Lower expenses (25-35%) due to minimal maintenance

    Market lease rates and vacancy rates are specific to each property type and geographic location, reflecting local market conditions.

    Disclaimer

    These calculations are estimates for informational purposes only and should not be used as a substitute for professional financial analysis or appraisal.

    • Cap Rate calculations depend on market data that may change over time
    • Actual operating expenses, lease rates, and vacancy rates may differ from market averages
    • Individual property conditions, lease terms, and tenant quality significantly impact actual NOI
    • Property value estimates are approximations and not official appraisals
    • Cap rates vary widely by market, property condition, and investment risk profile

    Professional Guidance Recommended: Before making any investment or financial decisions, consult with licensed appraisers, commercial real estate brokers, and financial advisors who can evaluate your specific property and circumstances.
    By using this feature, you acknowledge that Realmo is not responsible for investment decisions or actions taken based on these estimates.

    Cap approach

    Capitalization Method calculates value based on estimated net operating income (NOI) and applying a market-based capitalization rate (cap rate), we estimate what a typical investor might be willing to pay for it.

    Comparable approach

    Comparable estimate is based on recent sales of similar nearby properties, adjusted for factors like size, condition, and location.

    Relative

    Relative property class coefficient uses factors that account for typical price differences between various asset types (e.g., retail vs. industrial) to provide a more accurate market-aligned estimate.

    Geo

    Comparable Sales Method, enhanced by Geo coefficients — location-based adjustment factors that reflect differences in price levels across neighborhoods, cities, or regions ensuring a more accurate, market-sensitive valuation.

    Stat Estimate

    This method estimates value based on actual market adjusted recent (~5 years) sales of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all similar sales ($/sqft) are above this value
    • Range-to: 75% of all similar sales ($/sqft) are below this value
    AI Estimate

    This method estimates value based on AI market estimation of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all estimations ($/sqft) are above this value
    • Range-to: 75% of all estimations ($/sqft) are below this value
    Alternative use

    Estimate considers the property’s potential value if used for a different purpose-based on zoning, demand, and market feasibility.

    More about this property
    Thanks! Your message was sent.
    Error! Your message wasn't sent.
    Please enter your name
    Please enter email
    Please enter the email in the correct format
    Please enter phone
    Please enter the number in the correct format
    Please enter message
    Thank You

    You are Unsubscribed From Notifications

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!