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    High-Tech Biotech Facility For Sale Title is generated by Realmo AI

    SOUTH SAN FRANCISCO, South San Francisco 94080

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    New
    For Sale
    $48,000,000

    COMMERCIAL - SOUTH SAN FRANCISCO

    Property size:
    21,552 SF
    Lot size:
    3.65 Acres
    Price / SF:
    $2,227/SF
    Added:
    May 20, 2026
    Days on Market:
    4
    Last Refresh:
    May 23 at 12:06 pm

    Property Features for SOUTH SAN FRANCISCO

    General Information

    Property type
    Commercial Sale
    Property subtype
    Other
    Zoning
    MH00M2
    Rooms
    Office
    Parking
    62
    Parking features
    Off Street, Garage, Assigned, Guest, Covered
    Security features
    Security Alarm, Security
    Interior features
    High Ceiling, Security Gate
    Fencing
    Gate
    Standard status
    Active
    Size
    21,552 SF
    Lot size
    3.65 Acres

    Utilities

    Heating system
    Forced Air
    Cooling system
    Central Air
    Water source
    Public

    Building Details

    Year built
    2019
    Flooring type
    Concrete, Carpet
    Roof type
    Elastomeric, Metal, Flat

    We can help!

    Listing Contact
    John Tran

    Listing agent John Tran License #02092278

    Listing office KW Elevate 5201 Great America Pkwy, Suite 138, Santa Clara, CA

    Listing date May 20, 2026

    MLS# ML82044309

    Copyright © 2026 MLS Listings, Inc. All rights reserved. All information provided by the listing agent/broker is deemed reliable but is not guaranteed and should be independently verified.

    HighLights

    • Fully secured, mission‑critical biotech facility with a federal tenant, providing stable income.
    • Purpose‑built in 2019 with specialized laboratory infrastructure, including entomology and botany labs with advanced features.
    • Redundant systems: 500kW stand‑alone diesel generator and UPS backup power for operational continuity.
    • Advanced security features: Lenel card reader system, 24‑hour CCTV, shatter‑resistant blast‑mitigation windows.
    • Strategic location in the heart of the global biotech cluster with immediate access to major transit corridors.
    • Streamlined logistics: 4 interior dock‑high doors within a secure devanning area for 53‑foot tractor‑trailers.

    Overview

    This premier 21,552 SF high-tech facility, purpose-built in 2019, is situated on a 3.65-acre site. Located in the heart of the global biotech cluster, it offers specialized laboratory infrastructure, advanced security, and immediate access to major transit corridors. The interior features approximately 9,500 SF of professional office space, 4,500 SF of mission-critical lab space, and a 7,000 SF warehouse/inspection zone. The build-out includes multiple entomology and botany labs with phenolic resin countertops, 100% ducted exhaust (8 air changes/hour), and high-purity reverse osmosis water systems. A 500kW stand-alone diesel generator and dedicated UPS backup power ensure operational continuity. Logistics are streamlined via 4 interior dock-high doors within a secure devanning area for 53-foot tractor-trailers. This Security Level II facility is fortified with a Lenel card reader system, 24-hour CCTV, shatter-resistant blast-mitigation windows, and a fenced parking area with 62 assigned spaces. The property is zoned MH00M2 and is currently used as commercial real estate, manufacturing, industrial, office units, office spaces, and warehouses.
    Location Intelligence

    Current Use by Public Records

    Manufacturing properties

    Map

    City
    South San Francisco
    County
    San Mateo
    State
    Longitude
    -122.426
    Latitude
    37.6562

    FAQs

    What type of property is this?
    Manufacturing property - Premier 21,552 SF high-tech facility in South San Francisco.
    Where is this manufacturing property located?
    The property is located at SOUTH SAN FRANCISCO South San Francisco.
    What is the asking price?
    The asking price for this property is $48,000,000.
    What are key features of this property?
    This property features: Fully secured, mission‑critical biotech facility with a federal tenant, providing stable income.; Purpose‑built in 2019 with specialized laboratory infrastructure, including entomology and botany labs with advanced features.; Redundant systems: **500kW stand‑alone diesel generator and UPS backup power** for operational continuity.
    (408) 931-0897
    We can help!
    Listing Contact
    John Tran
    Real Estate License ID: 02092278
    Learn More
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    Realmo Value Estimations

    Realmo estimates a property’s market value using a proprietary methodology that incorporates public data and user-submitted information. This cumulative value is generated by integrating a variety of conventional and innovative methods. 

    Disclaimer

    These figures are not official appraisals and should not be used as a substitute for a valuation performed by a licensed appraiser.
    Actual market value may differ due to factors not captured in the data. Estimates are offered for informational purposes only, and users should conduct independent research before making financial or investment decisions.
    By using this feature, you acknowledge that Realmo is not responsible for actions taken based on these estimates.

    AI approach

    Realmo AI Method estimates property value using machine learning models trained on millions of comparable listings, transactions, and market signals. It analyzes property features, location intelligence data, and current market dynamics to predict the most probable market value in real time.

    Realmo CapRate Calculation

    Realmo calculates the Capitalization Rate (Cap Rate) to help estimate a property's potential return on investment. The Cap Rate is a fundamental metric in commercial real estate that measures the relationship between a property's net operating income and its market value.

    How We Calculate Cap Rate

    Cap Rate Formula:
    Cap Rate (%) = (Net Operating Income / Property Value) × 100

    Net Operating Income (NOI) Formula:
    NOI = Area × Lease Rate × (1 - Vacancy Rate) × (1 - Operating Expense Ratio)

    Components

    Net Operating Income (NOI) represents the annual income a property generates after operating expenses:

    • Area: Building square footage from property records
    • Lease Rate: Annual $/sqft based on market data for the property type and geographic location
    • Vacancy Rate: Percentage of unoccupied space based on market data for the property type and location
    • Operating Expense Ratio: Operating costs as a percentage of income, varies by property type

    Property Value is derived from:

    • Recent sale price (if available)
    • Statistical models using comparable sales
    • AI-powered valuation estimates

    Example Calculation

    For a 100,000 sqft Office Building:

    • Lease Rate: $25.00/sqft/year (market data for Office in this area)
    • Vacancy Rate: 8% (market data for Office in this area)
    • Operating Expense Ratio: 35% (typical for Office properties)
    • Property Value: $15,000,000

    Step 1: Calculate NOI

    NOI = 100,000 × $25.00 × (1 - 0.08) × (1 - 0.35)
    NOI = 100,000 × $25.00 × 0.92 × 0.65
    NOI = $1,495,000/year

    Step 2: Calculate Cap Rate

    Cap Rate = ($1,495,000 / $15,000,000) × 100
    Cap Rate = 9.97%

    Property Type Considerations

    Net Operating Income calculations vary by property type due to different operating expense ratios:

    • Office: Higher expenses (30-40%) for HVAC, utilities, maintenance
    • Retail: Moderate expenses (25-35%) for common area maintenance
    • Industrial/Warehouse: Lower expenses (15-25%) for minimal tenant services
    • Multifamily: Moderate expenses (35-45%) including property management
    • Self-Storage: Lower expenses (25-35%) due to minimal maintenance

    Market lease rates and vacancy rates are specific to each property type and geographic location, reflecting local market conditions.

    Disclaimer

    These calculations are estimates for informational purposes only and should not be used as a substitute for professional financial analysis or appraisal.

    • Cap Rate calculations depend on market data that may change over time
    • Actual operating expenses, lease rates, and vacancy rates may differ from market averages
    • Individual property conditions, lease terms, and tenant quality significantly impact actual NOI
    • Property value estimates are approximations and not official appraisals
    • Cap rates vary widely by market, property condition, and investment risk profile

    Professional Guidance Recommended: Before making any investment or financial decisions, consult with licensed appraisers, commercial real estate brokers, and financial advisors who can evaluate your specific property and circumstances.
    By using this feature, you acknowledge that Realmo is not responsible for investment decisions or actions taken based on these estimates.

    Cap approach

    Capitalization Method calculates value based on estimated net operating income (NOI) and applying a market-based capitalization rate (cap rate), we estimate what a typical investor might be willing to pay for it.

    Comparable approach

    Comparable estimate is based on recent sales of similar nearby properties, adjusted for factors like size, condition, and location.

    Relative

    Relative property class coefficient uses factors that account for typical price differences between various asset types (e.g., retail vs. industrial) to provide a more accurate market-aligned estimate.

    Geo

    Comparable Sales Method, enhanced by Geo coefficients — location-based adjustment factors that reflect differences in price levels across neighborhoods, cities, or regions ensuring a more accurate, market-sensitive valuation.

    Stat Estimate

    This method estimates value based on actual market adjusted recent (~5 years) sales of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all similar sales ($/sqft) are above this value
    • Range-to: 75% of all similar sales ($/sqft) are below this value
    AI Estimate

    This method estimates value based on AI market estimation of comparable properties around by location and property type.

    • Ranges - area data calculated by industry standard IQR Outlier Removal Method
    • Range-from: 75% of all estimations ($/sqft) are above this value
    • Range-to: 75% of all estimations ($/sqft) are below this value
    Alternative use

    Estimate considers the property’s potential value if used for a different purpose-based on zoning, demand, and market feasibility.

    More about this property
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