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Mixed-Use Retail and Residence

4506 220th Trl, Amana, IA 52203

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For Sale

$575,000

COMMERCIAL - Amana, IA

Property size:

5,959 SF

Lot size:

0.35 Acres

Price / SF:

$96/SF

HighLights

Distinctive brick mixed‑use building built in 1856 with central air and natural gas forced‑air heating
Approx. 3,559 finished SF on the main level plus approx. 2,400 finished SF on the second level (approx. 5,959 total finished SF)
Includes upper‑level living quarters with living & dining rooms, full kitchen, 3 full bathrooms, 2.5 additional baths, and a dedicated laundry room
Main level offers expansive commercial space with potential to extend use into the second floor or keep the upper level as residential or rental
Four Winds Apothecary to vacate by end of February 2026
Sale includes three separate parcels: 104009082, 104009086, 104009088

We can help!

Contact an agent

Terri Larson

For Sale

$575,000

COMMERCIAL - Amana, IA

Property size:

5,959 SF

Lot size:

0.35 Acres

Price / SF:

$96/SF

Added:: Feb 11, 2026
Days on Market:: 146
Last Refresh:: Jul 7 at 11:06 am

Property Features for 4506 220th Trl

General Information

Property type: Commercial Sale
Property subtype: Other
Zoning: Commercial
Standard status: Active
APN: 104009082*
Lot size: 0.35 Acres

Taxes and HOA fees

Tax Year: 2024
Tax Annual Amount: 4836

Utilities

Heating system: Natural Gas, Forced Air
Cooling system: Central Air

Building Details

Year built: 1856
Flooring type: Wood, Carpet
Building materials: Brick
Roof type: Composition

We can help!

Contact an agent

Terri Larson

Listing agent Terri Larson

Listing office Lepic-Kroeger, REALTORS 2346 MORMON TREK BLVD SUITE #2000, Iowa City, IA

Listing date Feb 11, 2026

MLS# 202601101

Copyright © 2026 Iowa City Area Association of REALTORS®. All rights reserved. All information provided by the listing agent/broker is deemed reliable but is not guaranteed and should be independently verified.

HighLights

Distinctive brick mixed‑use building built in 1856 with central air and natural gas forced‑air heating
Approx. 3,559 finished SF on the main level plus approx. 2,400 finished SF on the second level (approx. 5,959 total finished SF)
Includes upper‑level living quarters with living & dining rooms, full kitchen, 3 full bathrooms, 2.5 additional baths, and a dedicated laundry room
Main level offers expansive commercial space with potential to extend use into the second floor or keep the upper level as residential or rental
Four Winds Apothecary to vacate by end of February 2026
Sale includes three separate parcels: 104009082, 104009086, 104009088

Overview

This mixed-use property offers flexible space for commercial, residential, or live/work use. The main level provides approximately 3,559 finished square feet of commercial space, with the option to extend that commercial use into the second floor, or keep the main floor commercial while using the upper level as a private residence or a rental. The second level adds approximately 2,400 finished square feet and includes living and dining rooms, a full kitchen, multiple bathrooms, and a dedicated laundry room. The sale includes three separate parcels (104009082, 104009086, 104009088). All square footage and property taxes are to be verified by the buyer.

Located at 4506 220th Trl in Amana, the property is positioned among the village’s established retail businesses. The current tenant, Four Winds Apothecary, is reported to vacate by the end of February 2026.

For tenants, operators, or owners seeking versatility, the building’s split-use configuration allows a business to occupy the ground floor while the upper level functions as owner-occupied living or an additional income-producing unit. The combined total of approximately 5,959 finished square feet supports multiple operating scenarios, including maintaining retail downstairs and reserving the residential component above.

Property Profile Location Intelligence

Current Use by Public Records

Catiri's Art Oasis Art Gallery

Suggested Use

Location Insight

Map
Local Demand

City: Amana
County: Iowa
State: Iowa
Longitude: -91.870468
Latitude: 41.799732

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$575,000

5,959 SF

Mixed-Use Property in Prime Location

Unique mixed-use property with commercial and residential potential.

4506 220th Trl, Amana, IA 52203

View Details

For sale
Live-work space
IA
Amana
52203
4506 220th Trl

What type of property is this?

Live-work space - Two-level mixed-use layout supports retail on the main floor and an upstairs residence or rental option.

Where is this live-work space located?

The property is located at 4506 220th Trl Amana, IA.

What is the asking price?

The asking price for this property is $575,000.

What are key features of this property?

This property features: Distinctive brick mixed‑use building built in 1856 with central air and natural gas forced‑air heating; Approx. 3,559 finished SF on the main level plus approx. 2,400 finished SF on the second level (approx. 5,959 total finished SF); Includes upper‑level living quarters with living & dining rooms, full kitchen, 3 full bathrooms, 2.5 additional baths, and a dedicated laundry room

4506 220th Trl, Amana, IA 52203

COMMERCIAL - Amana, IA

Property Features for 4506 220th Trl

General Information

Taxes and HOA fees

Utilities

Building Details

We can help!

HighLights

Overview

Current Use by Public Records

Suggested Use

Location Insight

Nearby Similar for Sale

Event Center with Commercial Kitchen

Mixed-Use Property in Prime Location

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