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    Desoto County, FL Commercial Real Estate for Sale

    120 results
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    Arcadia Mixed-Use Opportunity on Highway
    $3,950,000
    94,986 SF

    Arcadia Mixed-Use Opportunity on Highway

    5871 Highway 31 SE, Arcadia, FL 34266

    Mixed-use property on 17 acres near major routes.

    • Large 17‑acre property directly off Hwy 31 in South DeSoto County.
    • Multiple buildings with rooms, bathrooms, office space, and cafeteria.
    • Convenient location: 20‑30 minutes to Babcock Ranch, Ft Myers, Punta Gorda, and I‑75.
    • Potential for industrial or housing development.
    • Possible seller financing available.
    Updated: Mar 20, 2025
    View details
    Arcadia Mixed-Use Development Opportunity
    $4,500,000
    136,190 SF

    Arcadia Mixed-Use Development Opportunity

    6000 Highway 31 SE, Arcadia, FL 34266

    73+ acres with Hwy 31 frontage, near Fort Myers.

    • Prime development opportunity with URBAN CENTER future land use designation.
    • Substantial acreage: 73+ acres suitable for large‑scale development.
    • Extensive Hwy 31 frontage: Over a half mile of direct highway access.
    • Strategic location: Just 5 minutes South of Arcadia, Florida.
    • Convenient access to Fort Myers, Interstate 75, and the Gulf Coast.
    Updated: Sep 23, 2025
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    Versatile Commercial Property in Arcadia, FL
    $299,000
    1,059 SF

    Versatile Commercial Property in Arcadia, FL

    Adaptable commercial space with office and open layout, prime location.

    811 N Mills Ave, Arcadia, FL 34266
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    Commercial Property on Highway 17
    $975,000
    7,034 SF

    Commercial Property on Highway 17

    2.93-acre commercial property suitable for retail, office, or educational use.

    5241 Highway 17 SW, Arcadia, FL 34266
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    Medical Office in Prime Location
    $349,000
    1,968 SF

    Medical Office in Prime Location

    Updated medical office space near hospital with rental income potential.

    303 E Gibson St, Arcadia, FL 34266
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    Arcadia Commercial Space on Highway
    $850,000
    2.83 Acres

    Arcadia Commercial Space on Highway

    21,000+ SqFt space near Arcadia, Florida, on 2.83 acres.

    5673 Highway 31 SE, Arcadia, FL 34266
    View details
    Arcadia Commercial Opportunity on 17 Acres
    $3,950,000
    17.00 Acres

    Arcadia Commercial Opportunity on 17 Acres

    Multiple buildings on 17 acres near Hwy 31.

    5871 SE Highway 31, Arcadia, FL 34266
    View details
    ARCADIA, FL Mixed-Use Space
    $850,000
    21,003 SF

    ARCADIA, FL Mixed-Use Space

    21,000+ SqFt mixed-use space near Arcadia and major cities.

    5673 Highway 31 SE, Arcadia, FL 34266
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    Ice Cream Shop Business Opportunity
    $99,000

    Ice Cream Shop Business Opportunity

    Thriving ice cream shop business for sale in downtown Arcadia.

    203 W Oak St, Arcadia, FL 34266
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    315 Oak St, Arcadia, FL 34266
    $339,000
    2,584 SF

    315 Oak St, Arcadia, FL 34266

    Mixed-use properties • 2,584 SF

    315 Oak St, Arcadia, FL 34266
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    Arcadia Office Building - Great Location!
    $349,000
    1,059 SF

    Arcadia Office Building - Great Location!

    Versatile office space, ample parking, move-in ready.

    811 Mills Ave, Arcadia, FL 34266
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    Arcadia Office/Warehouse Opportunity
    $850,000
    31,929 SF

    Arcadia Office/Warehouse Opportunity

    Spacious Office & Shop, Hwy 31 Access

    5673 Highway 31, Arcadia, FL 34266
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    Arcadia Mixed-Use Development Opportunity
    $5,000,000
    94,986 SF

    Arcadia Mixed-Use Development Opportunity

    17 Acres, 95,000 SF, High Visibility

    5871 Highway 31, Arcadia, FL 34266
    View details
    Arcadia Mixed-Use Commercial Property
    $850,000
    31,929 SF

    Arcadia Mixed-Use Commercial Property

    Large Warehouse/Shop Conversion Opportunity

    5673 Highway 31, Arcadia, FL 34266
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    Arcadia Mixed-Use Property
    $1,100,000
    8,509 SF

    Arcadia Mixed-Use Property

    Live, Work, Worship on 4 Acres

    7538 Cubitis Ave, Arcadia, FL 34266
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    Arcadia Mixed-Use Waterfront Property
    $900,000
    4,720 SF

    Arcadia Mixed-Use Waterfront Property

    Waterfront venue, huge potential!

    2124 American Legion Dr, Arcadia, FL 34266
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    Arcadia Commercial Building - High ROI
    $1,299,990
    7,266 SF

    Arcadia Commercial Building - High ROI

    High-income producing property, excellent location.

    920 Mills Ave, Arcadia, FL 34266
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    Arcadia Office Building - Hwy 17
    $610,000
    1,984 SF

    Arcadia Office Building - Hwy 17

    High-visibility office building, prime location.

    1020 Mills Ave, Arcadia, FL 34266
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    Florida Medical Office Building
    $608,888
    2,055 SF

    Florida Medical Office Building

    Arcadia, FL - Net Lease Investment

    810 Mills Ave, Arcadia, FL 34266
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    Arcadia Event Center & Restaurant
    $2,500,000
    12,000 SF

    Arcadia Event Center & Restaurant

    Florida Event Venue & Restaurant Opportunity

    3327 Us-17, Arcadia, FL 34266
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    Arcadia Retail Property For Sale
    $2,700,000
    3,721 SF

    Arcadia Retail Property For Sale

    Retail property available for purchase in Arcadia, Florida.

    9836 SW County Road 761, Arcadia, FL 34269
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    Arcadia Medical Office For Sale
    $525,000
    2,055 SF

    Arcadia Medical Office For Sale

    Medical office building with 2,055 square feet in Arcadia, FL.

    810 N Mills Ave, Arcadia, FL 34266
    View details
    New Wheelhouse Garages For Sale
    $1,990,000

    New Wheelhouse Garages For Sale

    Five new, never-occupied Wheelhouse garages available in Nocatee, Florida.

    950 Cross Town Dr, Nocatee, FL 32081
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    Arcadia Commercial Property For Sale
    Contact for pricing

    Arcadia Commercial Property For Sale

    Located in the heart of Arcadia, Florida, suitable for various uses.

    1401 Martin Luther King Jr St SW, Arcadia, FL 34266
    View details

    Desoto County, FL Commercial Real Estate Investment Opportunities Market Analysis

    Explore 738 commercial real estate investment opportunities in Desoto County, FL with 120 listings featured on our commercial real estate marketplace. The current inventory includes 656,682,819 square feet of properties with an estimated value of $358,021,764.

    Estimated prices for commercial real estate in Desoto County, FL begin at $30,000, with an average of $655,717 and extend to $32,975,000.

    In Desoto County, FL, current investment values show:

    • Retail properties positioned at $543,425
    • Industrial properties measuring $652,046
    • Warehouses assessed at $547,925
    • Other warehouses calculated at $446,917
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    Browse Commercial real estate for Sale Near Desoto, FL

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