Desoto County, FL commercial real estate for sale

Arcadia Medical/Professional Office For Sale

$299,900

1,968 SF

Arcadia Medical/Professional Office For Sale

303 E Gibson St, Arcadia, FL 34266

Well-located medical/professional office in Arcadia's medical district.

Prime location in Arcadia's established medical district, steps from DeSoto Memorial Hospital
Income‑producing space provides immediate revenue potential
Functional 1,968 sq ft layout ideal for medical or professional office use
Significant price reduction of $30,000
Large 0.52‑acre corner lot with excellent visibility, access, and on‑site parking

Updated: Feb 6

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Arcadia Mixed-Use Development Opportunity

$4,500,000

136,190 SF

Arcadia Mixed-Use Development Opportunity

6000 Highway 31 SE, Arcadia, FL 34266

73+ acres with Hwy 31 frontage, near Fort Myers.

Prime development opportunity with URBAN CENTER future land use designation.
Substantial acreage: 73+ acres suitable for large‑scale development.
Extensive Hwy 31 frontage: Over a half mile of direct highway access.
Strategic location: Just 5 minutes South of Arcadia, Florida.
Convenient access to Fort Myers, Interstate 75, and the Gulf Coast.

Updated: Sep 23, 2025

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$850,000

21,003 SF

ARCADIA, FL Mixed-Use Space

21,000+ SqFt mixed-use space near Arcadia and major cities.

5673 Highway 31 SE, Arcadia, FL 34266

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$975,000

7,034 SF

Commercial Property on Highway 17

2.93-acre commercial property suitable for retail, office, or educational use.

5241 Highway 17 SW, Arcadia, FL 34266

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Arcadia Mixed-Use Opportunity on Highway

$3,950,000

94,986 SF

Arcadia Mixed-Use Opportunity on Highway

Mixed-use property on 17 acres near major routes.

5871 Highway 31 SE, Arcadia, FL 34266

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Versatile Commercial Property in Arcadia, FL

$299,000

1,059 SF

Versatile Commercial Property in Arcadia, FL

Adaptable commercial space with office and open layout, prime location.

811 N Mills Ave, Arcadia, FL 34266

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$850,000

2.83 Acres

Arcadia Commercial Space on Highway

21,000+ SqFt space near Arcadia, Florida, on 2.83 acres.

5673 Highway 31 SE, Arcadia, FL 34266

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Arcadia Commercial Opportunity on 17 Acres

$3,950,000

17.00 Acres

Arcadia Commercial Opportunity on 17 Acres

Multiple buildings on 17 acres near Hwy 31.

5871 SE Highway 31, Arcadia, FL 34266

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$99,000

Ice Cream Shop Business Opportunity

Thriving ice cream shop business for sale in downtown Arcadia.

203 W Oak St, Arcadia, FL 34266

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$339,000

2,584 SF

315 Oak St, Arcadia, FL 34266

Mixed-use properties • 2,584 SF

315 Oak St, Arcadia, FL 34266

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Arcadia Office Building - Great Location!

$349,000

1,059 SF

Arcadia Office Building - Great Location!

Versatile office space, ample parking, move-in ready.

811 Mills Ave, Arcadia, FL 34266

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$850,000

31,929 SF

Arcadia Office/Warehouse Opportunity

Spacious Office & Shop, Hwy 31 Access

5673 Highway 31, Arcadia, FL 34266

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$5,000,000

94,986 SF

Arcadia Mixed-Use Development Opportunity

17 Acres, 95,000 SF, High Visibility

5871 Highway 31, Arcadia, FL 34266

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$850,000

31,929 SF

Arcadia Mixed-Use Commercial Property

Large Warehouse/Shop Conversion Opportunity

5673 Highway 31, Arcadia, FL 34266

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$1,100,000

8,509 SF

Arcadia Mixed-Use Property

Live, Work, Worship on 4 Acres

7538 Cubitis Ave, Arcadia, FL 34266

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$900,000

4,720 SF

Arcadia Mixed-Use Waterfront Property

Waterfront venue, huge potential!

2124 American Legion Dr, Arcadia, FL 34266

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$1,299,990

7,266 SF

Arcadia Commercial Building - High ROI

High-income producing property, excellent location.

920 Mills Ave, Arcadia, FL 34266

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$610,000

1,984 SF

Arcadia Office Building - Hwy 17

High-visibility office building, prime location.

1020 Mills Ave, Arcadia, FL 34266

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$608,888

2,055 SF

Florida Medical Office Building

Arcadia, FL - Net Lease Investment

810 Mills Ave, Arcadia, FL 34266

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$2,500,000

12,000 SF

Arcadia Event Center & Restaurant

Florida Event Venue & Restaurant Opportunity

3327 Us-17, Arcadia, FL 34266

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$299,000

Versatile Commercial Property For Sale

Adaptable commercial space suitable for retail, office, or service businesses.

811 Mills Ave, Arcadia, FL 34266

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$2,700,000

3,721 SF

Arcadia Retail Property For Sale

Retail property available for purchase in Arcadia, Florida.

9836 SW County Road 761, Arcadia, FL 34269

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$525,000

2,055 SF

Arcadia Medical Office For Sale

Medical office building with 2,055 square feet in Arcadia, FL.

810 N Mills Ave, Arcadia, FL 34266

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Contact for pricing

Arcadia Commercial Property For Sale

Located in the heart of Arcadia, Florida, suitable for various uses.

1401 Martin Luther King Jr St SW, Arcadia, FL 34266

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Desoto County, FL Commercial Real Estate Investment Opportunities Market Analysis

Explore 739 commercial real estate investment opportunities in Desoto County, FL with 111 listings featured on our commercial real estate marketplace. The current inventory includes 659,305,567 square feet of properties with an estimated value of $350,039,976.

Estimated prices for commercial real estate in Desoto County, FL begin at $37,500, with an average of $650,631 and extend to $32,975,000.

In Desoto County, FL, current investment values show:

Retail properties positioned at $543,425
Industrial properties measuring $652,046
Warehouses assessed at $547,925
Other warehouses calculated at $446,917

Desoto County, FL Commercial Real Estate for Sale

Arcadia Medical/Professional Office For Sale

Well-located medical/professional office in Arcadia's medical district.